产品说明书
ZAP-180013
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同义名 : | - |
| CAS号 : | 873080-25-2 | |
| 货号 : | A1359461 | |
| 分子式 : | C19H17Cl2N3O4S | |
| 纯度 : | 99%+ | |
| 分子量 : | 454.327 | |
| MDL号 : | MFCD07360519 | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 250 mg/mL(550.26 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | ZAP-70 (zeta-associated protein of 70 kDa) plays an essential role in T-cell signaling. Its misregulation can lead to immune-related diseases. ZAP-180013 is an inhibitor of ZAP-70 with an IC50 of 1.8 μM. ZAP-180013 inhibits the interaction of the ZAP-70 SH2 domain with immunoreceptor tyrosine-based activation motifs (ITAMs) with IC50s of 9.6 μM and 16.841 μM in FP and TR-FRET assays, respectively[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.20mL 0.44mL 0.22mL |
11.01mL 2.20mL 1.10mL |
22.01mL 4.40mL 2.20mL |
| 参考文献 |
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