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Indole-3-carbinol

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Chemical Structure| 700-06-1 同义名 : 吲哚-3-甲醇 ;I3C;3-Indolemethanol;NSC 525801;3-Indolylmethanol;1H-Indole-3-methanol;Indinol;3-hydroxymethyl Indole
CAS号 : 700-06-1
货号 : A135866
分子式 : C9H9NO
纯度 : 98%
分子量 : 147.174
MDL号 : MFCD00005632
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(713.44 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1). I3C inhibits the proliferation of THP-1 cells in a dose- and time-dependent manner with minimal toxicity over normal monocytes. I3C could exert its antileukemic effects through AhR activation which is associated with programed cell death and G1 cell cycle arrest in a dose- and time-dependent manner[3]. Treatment with I3C led to repressed colonic inflammation and prevention of microbial dysbiosis caused by colitis, increasing a subset of gram-positive bacteria known to produce butyrate. I3C attenuates colitis primarily through induction of IL-22, which leads to modulation of gut microbiota that promote antiinflammatory butyrate[4]. I3C prevented EtOH (ethanol) -induced liver injury via attenuating the damaging effect of ethanol on the gut-liver-adipose tissue axis[5]. I3C may induce apoptosis in human osteosarcoma MG-63 and U2OS cells via the activation of apoptotic signaling pathways by FOXO3[6].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00910884 - Not yet recruiting February 2020 United States, Washington ... 展开 >> Brabant Research, Incorporated Not yet recruiting Spokane Valley, Washington, United States, 99216 Contact: Richard E. Lasker, PhD    509-340-9902    rel@brabantresearch.com 收起 <<
NCT02483624 SLE Phase 1 Terminated - -
NCT02525159 Breast Cancer Phase 3 Completed - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

6.79mL

1.36mL

0.68mL

33.97mL

6.79mL

3.40mL

67.95mL

13.59mL

6.79mL
参考文献

[1]Mohammadi S, Seyedhosseini FS, et al. Indole-3-carbinol induces G1 cell cycle arrest and apoptosis through aryl hydrocarbon receptor in THP-1 monocytic cell line. J Recept Signal Transduct Res. 2017 Oct;37(5):506-514.

[2]Ampofo E, Lachnitt N, et al. Indole-3-carbinol is a potent inhibitor of ischemia-reperfusion-induced inflammation. J Surg Res. 2017 Jul;215:34-46.

[3]Mohammadi S, Seyedhosseini FS, Behnampour N, Yazdani Y. Indole-3-carbinol induces G1 cell cycle arrest and apoptosis through aryl hydrocarbon receptor in THP-1 monocytic cell line. J Recept Signal Transduct Res. 2017 Oct;37(5):506-514

[4]Busbee PB, Menzel L, Alrafas HR, Dopkins N, Becker W, Miranda K, Tang C, Chatterjee S, Singh U, Nagarkatti M, Nagarkatti PS. Indole-3-carbinol prevents colitis and associated microbial dysbiosis in an IL-22-dependent manner. JCI Insight. 2020 Jan 16;5(1):e127551

[5]Choi Y, Abdelmegeed MA, Song BJ. Preventive effects of indole-3-carbinol against alcohol-induced liver injury in mice via antioxidant, anti-inflammatory, and anti-apoptotic mechanisms: Role of gut-liver-adipose tissue axis. J Nutr Biochem. 2018 May;55:12-25

[6]Lee CM, Lee J, Nam MJ, Park SH. Indole-3-Carbinol Induces Apoptosis in Human Osteosarcoma MG-63 and U2OS Cells. Biomed Res Int. 2018 Nov 29;2018:7970618