产品说明书

WZB117

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Chemical Structure| 1223397-11-2 同义名 : -
CAS号 : 1223397-11-2
货号 : A135447
分子式 : C20H13FO6
纯度 : 99+%
分子量 : 368.312
MDL号 : MFCD24387113
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 145 mg/mL(393.69 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

IP 2% DMSO+2% Tween80+40% PEG300+water 6 mg/mL clear

PO 0.5% CMC-Na 36 mg/mL suspension

生物活性
靶点

  • GLUT1

    GLUT1, IC50:10μM
描述 WZB117 is a glucose transporter 1 (Glut1) inhibitor, which downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo[1]. WZB117 impedes glucose transport into cancer cells in a dose-responsive manner as shown by glucose uptake assays. This blockage occurs rapidly, within 1 minute of assay initiation, indicating a direct and swift mode of action. Cell viability assays demonstrate WZB117's capacity to inhibit cancer cell proliferation with an IC50 value around 10 μM. Clonogenic assays further validate WZB117's suppressive effect on cancer cell growth, suggesting this effect is irreversible. WZB117 treatment leads to more pronounced growth inhibition in lung cancer A549 cells compared to non-tumorigenic NL20 lung cells, with similar trends observed between breast cancer MCF7 cells and non-tumorigenic MCF12A cells. Under hypoxic conditions, cancer cells exhibit increased sensitivity to WZB117 compared to normoxic conditions[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.72mL

0.54mL

0.27mL

13.58mL

2.72mL

1.36mL

27.15mL

5.43mL

2.72mL
参考文献

[1]Liu Y, et al. A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo. Mol Cancer Ther. 2012 Aug;11(8):1672-82.