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1,4-DPCA

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Chemical Structure| 331830-20-7 同义名 : 1,4-dihydrophenonthrolin-4-one-3-Carboxylic acid
CAS号 : 331830-20-7
货号 : A1340294
分子式 : C13H8N2O3
纯度 : 98%
分子量 : 240.214
MDL号 : N/A
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 12 mg/mL(49.96 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 1,4-DPCA is a potent inhibitor of prolyl-4-hydroxylase with an IC50 of 2.4 µM in human foreskin fibroblasts. 1,4-DPCA can inhibit the α isoenzyme of prolyl-4-hydroxylase and stabilize HIF-1α protein. 1,4-DPCA also inhibits factors that inhibit HIF with an IC50 of 60 µM[1][2].In mouse B6 cells, 1,4-DPCA specifically increases the expression of several target genes, including the pro-angiogenic targets Vegfa and Hmox1, and the proglycolytic targets Ldh-a, Pgk1, Pdk1, and Glut1, after 24 hours of treatment[1].1,4-DPCA significantly reduced cell colony size in T4-2 (10 μM) and ZR-75-1 cells (20 μM). T4-2 cells treated with 1,4-DPCA formed polarised spheroids in three-dimensional cultures. 1,4-DPCA treatment significantly reduced invasive branching in DA-MB-157 (20 μM) and MDA-MB-231 (10 μM) cells[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.16mL

0.83mL

0.42mL

20.81mL

4.16mL

2.08mL

41.63mL

8.33mL

4.16mL
参考文献

[1]Yong Zhang, et al. Drug-induced regeneration in adult mice. Sci Transl Med. 2015 Jun 3;7(290):290ra92.

[2]Ryan J Love, et al. Transient inhibition of connective tissue infiltration and collagen deposition into porous poly(lactic-co-glycolic acid) discs. J Biomed Mater Res A. 2013 Dec;101(12):3599-606.

[3]Gaofeng Xiong, et al. Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition. BMC Cancer. 2014 Jan 2;14:1.