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Eragidomide

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Chemical Structure| 1860875-51-9 同义名 : CC-90009
CAS号 : 1860875-51-9
货号 : A1339730
分子式 : C22H18ClF2N3O4
纯度 : 99%+
分子量 : 461.846
MDL号 : MFCD32690104
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(227.35 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • CRBN
描述 Eragidomide (CC-90009), a pioneering GSPT1-selective modulator of the cereblon (CRBN) E3 ligase, functions as molecular glue. It recruits the CRL4CRBN complex to specifically earmark GSPT1 for ubiquitination and subsequent proteasomal elimination[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.17mL

0.43mL

0.22mL

10.83mL

2.17mL

1.08mL

21.65mL

4.33mL

2.17mL
参考文献

[1]Christine Surka, et al. CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells. Blood. 2021 Feb 4;137(5):661-677.

[2]Joshua D Hansen, et al. CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia. J Med Chem. 2021 Feb 25;64(4):1835-1843.