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COH34

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Chemical Structure| 906439-72-3 同义名 : -
CAS号 : 906439-72-3
货号 : A1339709
分子式 : C18H15NOS
纯度 : 99%+
分子量 : 293.383
MDL号 : MFCD32263032
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 16 mg/mL(54.54 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 COH34 is a highly potent and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG), exhibiting an IC50 value of 0.37 nM. It binds to PARG's catalytic domain with a Kd of 0.547 µM, which extends PARylation at DNA damage sites and traps DNA repair factors[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.41mL

0.68mL

0.34mL

17.04mL

3.41mL

1.70mL

34.09mL

6.82mL

3.41mL
参考文献

[1]Chen SH, et al. Targeting dePARylation selectively suppresses DNA repair-defective and PARP inhibitor-resistant malignancies. Sci Adv. 2019 Apr 10;5(4):eaav4340.