产品说明书

ACBI1

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Chemical Structure| 2375564-55-7 同义名 : -
CAS号 : 2375564-55-7
货号 : A1339706
分子式 : C49H58FN9O7S
纯度 : 98%
分子量 : 936.104
MDL号 : MFCD32689497
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(112.17 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 ACBI1 is a potent and synergistic degrader of SMARCA2, SMARCA4, and PBRM1 with DC50 values of 6, 11, and 32 nM, respectively. It functions as a PROTAC degrader, exhibiting anti-proliferative activity and inducing apoptosis[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.07mL

0.21mL

0.11mL

5.34mL

1.07mL

0.53mL

10.68mL

2.14mL

1.07mL
参考文献

[1]Farnaby W, et al. BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat Chem Biol. 2019 Jul;15(7):672-680.