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ONO-4059 analog

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Chemical Structure| 1351635-67-0 同义名 : GS-4059 analog;ONO-WG-307;ONO-4059 analogue
CAS号 : 1351635-67-0
货号 : A133954
分子式 : C25H24N6O3
纯度 : 98%
分子量 : 456.497
MDL号 : MFCD29049511
存储条件：

粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(109.53 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • BTK

    BTK, IC50:2.2 nM

  • BTK

    BTK, IC50:23.9 nM
描述 ONO-4059 is a highly potent and selective Btk inhibitor with an IC50 in the sub-nM range.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.19mL

0.44mL

0.22mL

10.95mL

2.19mL

1.10mL

21.91mL

4.38mL

2.19mL
参考文献

[1]Tomoko Y, Toshio Y, et al. ONO-4059, A Novel Bruton’s Tyrosine Kinase (Btk) Inhibitor: Synergistic Activity In Combination With Chemotherapy In a ABC-DLBCL Cell Line. Blood Journal. vol. 122 no. 21 5151. Published online December 5, 2013.

[2]Yoshizawa, Toshio, et al. Arthritis & Rheumatism, Volume 64, November 2012 Abstract Supplement