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NF-56-EJ40

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Chemical Structure| 2380230-73-7 同义名 : -
CAS号 : 2380230-73-7
货号 : A1339040
分子式 : C27H29N3O3
纯度 : 99%+
分子量 : 443.538
MDL号 : MFCD32263439
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 4 mg/mL(9.02 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 4 mg/mL(9.02 mM)，配合低频超声，并调节pH至9
动物实验配方：
生物活性
描述 NF-56-EJ40 is a potent and highly selective antagonist of human SUCNR1 (GPR91), demonstrating high affinity with an IC50 value of 25 nM and a Ki of 33 nM. It exhibits minimal activity against rat SUCNR1. Notably, NF-56-EJ40 possesses significant affinity for humanized rat SUCNR1, with a Ki of 17.4 nM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.25mL

0.45mL

0.23mL

11.27mL

2.25mL

1.13mL

22.55mL

4.51mL

2.25mL
参考文献

[1]Haffke M, et al. Structural basis of species-selective antagonist binding to the succinate receptor. Nature. 2019 Oct;574(7779):581-585.