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Ethynodiol Diacetate

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Chemical Structure| 297-76-7 同义名 : Ethynodiol acetate;SC-11800
CAS号 : 297-76-7
货号 : A133132
分子式 : C24H32O4
纯度 : 98%
分子量 : 384.509
MDL号 : MFCD00083326
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 145 mg/mL(377.1 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

IP 2% DMSO+2% Tween80+30% PEG300+water 4 mg/mL clear

PO 0.5% CMC-Na 70 mg/mL suspension

生物活性
描述 Ethynodiol diacetate is a steroidal progestin which is used as a hormonal contraceptive, it has relatively little or no potency as an androgen,has significant estrogenic effects.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.60mL

0.52mL

0.26mL

13.00mL

2.60mL

1.30mL

26.01mL

5.20mL

2.60mL
参考文献

[1]Siddique YH, Ara G, et al. Protective role of nordihydroguaiaretic acid (NDGA) against the genotoxic damage induced by ethynodiol diacetate in human lymphocytes in vitro. J Environ Biol. 2007 Apr;28(2):279-82.

[2]Simic B, Kniewald J, et al. Influence of Ethynodiol Diacetate on the Formation of A-Homo-3Oxa-5?-Pregnane-4,20-Dione in Female Rats. Endocr Regul. 1998 Sep;32(3):125-131.