产品说明书

MC1568

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Chemical Structure| 852475-26-4 同义名 : -
CAS号 : 852475-26-4
货号 : A133036
分子式 : C17H15FN2O3
纯度 : 96%
分子量 : 314.311
MDL号 : N/A
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 18 mg/mL(57.27 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

IP 2% DMSO+2% Tween80+40% PEG300+water 0.5 mg/mL clear

PO 0.5% CMC-Na 40 mg/mL suspension

生物活性
靶点

  • HD1

    HD1-B (Maize), IC50:3.4 μM

    HD1-A (Maize), IC50:100 nM
描述 MC1568 is a selective class II (IIa) histone deacetylas (HDAC II) inhibitor with IC50 of 220 nM and 176-fold class II selectivity (against class I).
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.18mL

0.64mL

0.32mL

15.91mL

3.18mL

1.59mL

31.82mL

6.36mL

3.18mL
参考文献

[1]Duong V, Bret C, et al. Specific activity of class II histone deacetylases in human breast cancer cells. Mol Cancer Res. 2008 Dec;6(12):1908-19.

[2]Mai A, Massa S, et al. Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel(aryloxopropenyl)pyrrolyl hydroxyamides. J Med Chem. 2005 May 5;48(9):3344-53.