1-Dodecylimidazole

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Chemical Structure| 4303-67-7 同义名 : N-Dodecylimidazole
CAS号 : 4303-67-7
货号 : A132963
分子式 : C15H28N2
纯度 : 97%
分子量 : 236.396
MDL号 : MFCD00278859
存储条件:

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(444.17 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 1-Dodecylimidazole (N-Dodecylimidazole) acts as a lysosomotropic detergent and cytotoxic agent, inducing cell death via acid-dependent accumulation in lysosomes, disruption of lysosomal membranes, and release of cysteine proteases into the cytoplasm. It also exhibits hypocholesterolaemic and broad-spectrum antifungal activities [1][2][3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.23mL

0.85mL

0.42mL

21.15mL

4.23mL

2.12mL

42.30mL

8.46mL

4.23mL

参考文献

[1]Wilson PD, et al. A relationship between multidrug resistance and growth-state dependent cytotoxicity of the lysosomotropic detergent N-dodecylimidazole. Biochem Biophys Res Commun. 1991;176(3):1377-1382.

[2]Atkin SD, et al. The isolation of 2,3-oxidosqualene from the liver of rats treated with 1-dodecylimidazole, a novel hypocholesterolaemic agent. Biochem J. 1972;130(1):153-157.

[3]Firestone RA, et al. Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents. J Med Chem. 1987;30(8):1519-1521.

[4]Boyer MJ, et al. pH dependent cytotoxicity of N-dodecylimidazole: a compound that acquires detergent properties under acidic conditions. Br J Cancer. 1993;67(1):81-87.