SKI V

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Chemical Structure| 24418-86-8 同义名 : -
CAS号 : 24418-86-8
货号 : A1329219
分子式 : C15H10O4
纯度 : 99%+
分子量 : 254.238
MDL号 : MFCD07772193
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(196.67 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 SKI V is a highly potent noncompetitive inhibitor of non-lipid sphingosine kinase (SPHK; SK), with an IC50 of 2 μM for GST-hSK. Additionally, SKI V exhibits potent inhibition of PI3K, with an IC50 of 6 μM for hPI3K. It effectively reduces the formation of the mitogenic second messenger sphingosine-1-phosphate (S1P). SKI V demonstrates apoptotic induction and displays significant antitumor activity[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.93mL

0.79mL

0.39mL

19.67mL

3.93mL

1.97mL

39.33mL

7.87mL

3.93mL
参考文献

[1]French KJ, et al. Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res. 2003 Sep 15;63(18):5962-9.

[2]French KJ, et al. Antitumor activity of sphingosine kinase inhibitors. J Pharmacol Exp Ther. 2006 Aug;318(2):596-603.