Orelabrutinib
产品说明书
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同义名 : | 奥拉布替尼 ;ICP-022 |
| CAS号 : | 1655504-04-3 | |
| 货号 : | A1329181 | |
| 分子式 : | C26H25N3O3 | |
| 纯度 : | 99%+ | |
| 分子量 : | 427.495 | |
| MDL号 : | MFCD32184857 | |
| 存储条件： |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(245.62 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Orelabrutinib (ICP-022) acts as a potent, orally active, and irreversible inhibitor of Bruton's tyrosine kinase (BTK), exhibiting potential antineoplastic properties. It blocks the activation of the B-cell antigen receptor (BCR) signaling pathway and BTK-dependent activation of downstream survival pathways, thereby inhibiting the proliferation of malignant B-cells that overexpress BTK [1][2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.34mL 0.47mL 0.23mL |
11.70mL 2.34mL 1.17mL |
23.39mL 4.68mL 2.34mL |
| 参考文献 |
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