产品说明书

MS1943

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Chemical Structure| 2225938-17-8 同义名 : -
CAS号 : 2225938-17-8
货号 : A1327306
分子式 : C42H54N8O3
纯度 : 99%+
分子量 : 718.93
MDL号 : MFCD32671554
存储条件:

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 120 mg/mL(166.91 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 MS1943 represents a pioneering orally bioavailable EZH2 selective degrader, demonstrating an IC50 value of 120 nM. It notably diminishes EZH2 protein levels across various triple-negative breast cancer (TNBC) and other cancer and noncancerous cell lines. Additionally, MS1943 robustly impedes the proliferation of multiple TNBC and other cancer cell lines[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.39mL

0.28mL

0.14mL

6.95mL

1.39mL

0.70mL

13.91mL

2.78mL

1.39mL

参考文献

[1]Ma A, et al. Discovery of a first-in-class EZH2 selective degrader.Nat Chem Biol. 2020 Feb;16(2):214-222.