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CD80-IN-3

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Chemical Structure| 486449-65-4 同义名 : -
CAS号 : 486449-65-4
货号 : A1327298
分子式 : C17H10FN3O3
纯度 : 99%+
分子量 : 323.278
MDL号 : MFCD32701897
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(108.27 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 CD80 is the dominant costimulatory receptor in immune responses. CD28 and CD152 are the most important T cell costimulatory ligands that engage CD80 and CD86 receptors on antigen-presenting cells. CD80-IN-3 is a potent, small-molecule inhibitor of CD80 with an EC50 value of 630nM and a KD value of 125nM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.09mL

0.62mL

0.31mL

15.47mL

3.09mL

1.55mL

30.93mL

6.19mL

3.09mL
参考文献

[1]Huxley P, Sutton DH, Debnam P, Matthews IR, Brewer JE, Rose J, Trickett M, Williams DD, Andersen TB, Classon BJ. High-affinity small molecule inhibitors of T cell costimulation: compounds for immunotherapy. Chem Biol. 2004 Dec;11(12):1651-8. doi: 10.1016/j.chembiol.2004.09.011