产品说明书

AMG 511

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Chemical Structure| 1253573-53-3 同义名 : -
CAS号 : 1253573-53-3
货号 : A1326767
分子式 : C22H28FN9O3S
纯度 : 99%+
分子量 : 517.58
MDL号 : MFCD25976575
存储条件:

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 35 mg/mL(67.62 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 AMG 511 is a potent pan inhibitor of class I PI3Ks, available orally, with Ki values of 4 nM, 6 nM, 2 nM, and 1 nM for PI3Kα, β, δ, and γ, respectively. It markedly inhibits PI3K signaling, as evidenced by a decrease in p-Akt (Ser473). Moreover, AMG 511 demonstrates anti-tumor efficacy in a mouse glioblastoma xenograft model[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.93mL

0.39mL

0.19mL

9.66mL

1.93mL

0.97mL

19.32mL

3.86mL

1.93mL

参考文献

[1]Mark H Norman, et al. Selective Class I Phosphoinositide 3-kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511. J Med Chem. 2012 Sep 13;55(17):7796-816.