生物活性 | |||
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描述 | AMG 511 is a potent pan inhibitor of class I PI3Ks, available orally, with Ki values of 4 nM, 6 nM, 2 nM, and 1 nM for PI3Kα, β, δ, and γ, respectively. It markedly inhibits PI3K signaling, as evidenced by a decrease in p-Akt (Ser473). Moreover, AMG 511 demonstrates anti-tumor efficacy in a mouse glioblastoma xenograft model[1]. |
实验方案 | |||
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1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
1.93mL 0.39mL 0.19mL |
9.66mL 1.93mL 0.97mL |
19.32mL 3.86mL 1.93mL |
参考文献 |
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