CH6953755

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Chemical Structure| 2055918-71-1 同义名 : -
CAS号 : 2055918-71-1
货号 : A1324875
分子式 : C26H22F2N6O4S
纯度 : 98%+
分子量 : 552.553
MDL号 : MFCD32693906
存储条件：

Pure form Inert atmosphere,Room Temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(217.17 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 CH6953755 is a potent, orally bioavailable, and selective inhibitor of YES1 kinase, a member of the SRC family, with an IC50 of 1.8 nM. Inhibition of YES1 kinase by CH6953755 results in antitumor effects against YES1 gene-amplified cancers both in vitro and in vivo[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.81mL

0.36mL

0.18mL

9.05mL

1.81mL

0.90mL

18.10mL

3.62mL

1.81mL
参考文献

[1]Hamanaka N, et al. YES1 Is a Targetable Oncogene in Cancers Harboring YES1 Gene Amplification. Cancer Res. 2019 Nov 15;79(22):5734-5745.