产品说明书

Liranaftate

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Chemical Structure| 88678-31-3 同义名 : Piritetrate;M-732
CAS号 : 88678-31-3
货号 : A131556
分子式 : C18H20N2O2S
纯度 : 98%
分子量 : 328.429
MDL号 : MFCD00865576
存储条件：

粉末 Keep in dark place,Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(319.7 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Liranaftate is a squalene epoxidase inhibitor with anti-fungicidal activities. Liranaftate showed excellent fungistatic activity against the conidia of T. rubrum. For each of these agents, the MIC after 14 days of contact was 0.009 g/ml. The liranaftate-induced decrease in the MCC occurred from 9 days onwards; MCC at 14 days was 0.039 g/ml[3]. Liranaftate with its potent fungicidal activities was suggested an efficacious agent for the treatment of dermatophytes[4]. Luliconazole was also highly active against Candida albicans (MIC range: 0.031-0.13 microg/ml), proving to be more potent than terbinafine, liranaftate, butenafine, amorolfine, and bifonazole, but less than ketoconazole, clotrimazole, neticonazole, and miconazole. Further, the MIC of luliconazole against Malassezia restricta, an important pathogenic agent involved in seborrhoeic dermatitis, was very low (MIC range: 0.004-0.016 microg/ml) suggesting action comparable to or stronger than that of ketoconazole[5]. Topical 20 microl administration of liranaftate in a dose-range between 1-4% suppressed the increase in ear thickness 6 hr after PMA (phorbol 12-myristate 13-acetate) application dose-dependently[6]. Clinically, liranaftate an antifungal drug with IL-8-decreasing activity may reduce infiltration of neutrophils in the skin and their invasion into the epidermis[7].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.04mL

0.61mL

0.30mL

15.22mL

3.04mL

1.52mL

30.45mL

6.09mL

3.04mL
参考文献

[1]Oku Y, Takahashi N, Yokoyama K. [Fungicidal activity of liranaftate against dermatophytes] . Nihon Ishinkin Gakkai Zasshi. 2009;50(1):9-13. Japanese.

[2]Oku Y, Sakuma K, Yokoyama K, Miyaji M. [Fungicidal activity of liranaftate against Trichophyton rubrum] . Nihon Ishinkin Gakkai Zasshi. 2002;43(3):181-7. Japanese.

[3]Oku Y, Sakuma K, Yokoyama K, Miyaji M. [Fungicidal activity of liranaftate against Trichophyton rubrum]. Nihon Ishinkin Gakkai Zasshi. 2002;43(3):181-7. Japanese

[4]Oku Y, Takahashi N, Yokoyama K. [Fungicidal activity of liranaftate against dermatophytes]. Nihon Ishinkin Gakkai Zasshi. 2009;50(1):9-13. Japanese

[5]Koga H, Nanjoh Y, Makimura K, Tsuboi R. In vitro antifungal activities of luliconazole, a new topical imidazole. Med Mycol. 2009;47(6):640-7

[6]Maruyama N, Abe Y, Hisajima T, Hayama K, Abe S. [Suppression of experimental inflammation by anti-fungal agent liranaftate in mice]. Nihon Ishinkin Gakkai Zasshi. 2010;51(1):7-11. Japanese

[7]Kobayashi M, Kabashima K, Tokura Y. [Anti-fungal drug liranaftate suppresses fungal element-promoted production of IL-8 in normal human keratinocytes]. Nihon Ishinkin Gakkai Zasshi. 2008;49(4):319-22. Japanese