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vitexin-2″-o-rhamnoside

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Chemical Structure| 64820-99-1 同义名 : 牡荆素-2-O-鼠李糖苷 ;Vitexin 2-O-rhamnoside;2''-O-Rhamnosylvitexin;Apigenin-8-C-glucoside;Vitexin-2"-O-rhamnoside
CAS号 : 64820-99-1
货号 : A131116
分子式 : C27H30O14
纯度 : 99%+
分子量 : 578.519
MDL号 : MFCD29913069
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(181.5 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Vitexin-2"-O-rhamnoside, a main flavonoid glycoside of the leaves of Cratagus pinnatifida Bge, contributes to the protection against H2O2-mediated oxidative stress damage and has potential to treat cardiovascular system diseases. VOR caused no cytotoxic effect on hADSCs (human adipose-derived stem cells) at concentrations up to 250μm[3]. The AUC of VOR was proportional to the dose after intravenous administration of 15, 30, 60 and 120 mg/kg body weight, and the elimination half-life (t1/2beta), systemic clearance (Cl) and apparent volume of distribution (Vc) were not significantly different among the four doses, and all the results indicated that the pharmacokinetics of VOR in rat obeyed first-order kinetics[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.73mL

0.35mL

0.17mL

8.64mL

1.73mL

0.86mL

17.29mL

3.46mL

1.73mL
参考文献

[1]Gao Y, Du Y, et al. Hepatic, gastric and intestinal first-pass effects of vitexin-2''-O-rhamnoside in rats by ultra-high-performance liquid chromatography. Biomed Chromatogr. 2016 Feb;30(2):111-6.

[2]Zhang W, Xu M, et al. Simultaneous determination of vitexin-4''-O-glucoside, vitexin-2''-O-rhamnoside, rutin and vitexin from hawthorn leaves flavonoids in rat plasma by UPLC-ESI-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Jul 1;878(21):1837-44.

[3]Wei W, Ying X, Zhang W, Chen Y, Leng A, Jiang C, Liu J. Effects of vitexin-2"-O-rhamnoside and vitexin-4"-O-glucoside on growth and oxidative stress-induced cell apoptosis of human adipose-derived stem cells. J Pharm Pharmacol. 2014 Jul;66(7):988-97

[4]Ying X, Gao S, Zhu W, Bi Y, Qin F, Li X, Li F. High-performance liquid chromatographic determination and pharmacokinetic study of vitexin-2''-O-rhamnoside in rat plasma after intravenous administration. J Pharm Biomed Anal. 2007 Jul 27;44(3):802-6