产品说明书
Imipramine hydrochloride
 |
同义名 : | 丙咪嗪盐酸盐 ;Imipramine (hydrochloride);Imipramine HCl;Melipramine |
| CAS号 : | 113-52-0 | |
| 货号 : | A131108 | |
| 分子式 : | C19H25ClN2 | |
| 纯度 : | 95% | |
| 分子量 : | 316.868 | |
| MDL号 : | MFCD00012669 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(331.37 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 60 mg/mL(189.35 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Imipramine HCl inhibits serotonin transporter with an IC50 value of 32 nM in vitro[2]. Imipramine (IMI) reduces pain-related negative emotion without influencing pain and that this effect is diminished by denervation of 5-HT neurons and by anti-BDNF (brain-derived neurotrophic factor) treatment. IMI also normalizes derangement of ERK/CREB coupling, which leads to induction of BDNF[3]. Moreover, imipramine treatment counteracts the corticosterone-induced increase in the reactivity of the hippocampal circuitry to the activation of the 5-HT7 receptor[1]. Administration of imipramine reverses social avoidance behavior, significantly increasing the interaction time. 24 days of imipramine treatment in RSD (repeated social defeat) mice significantly decreases stress-induced mRNA levels for IL-6 in brain microglia[4]. Chronic mild stress induces a long-term altered gene expression profile in the prefrontal cortex that is partially reverted by imipramine treatment (10 mg/kg, i.p.)[5]. Chronic imipramine administration altered the amino acid dynamics in the brain. In the striatum, the concentrations of asparagine, glutamine and methionine were significantly increased by chronic imipramine administration. In the thalamus and hypothalamus, chronic imipramine administration significantly decreased the valine concentration. In addition, lower concentration of asparagine in the prefrontal cortex of WKY rats (Wistar Kyoto rats, an animal model of depression) was improved by chronic imipramine administration[6]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT02191358 | - | Completed | - | United States, California ... 展开 >> Dr. Michael Dao Garden Grove, California, United States, 92844 United States, Colorado Kaiser Permanente Colorado Denver, Colorado, United States, 80011 United States, Kentucky Gill Heart Institute Lexington, Kentucky, United States, 40508 United States, Maryland IRC Clinics Towson, Maryland, United States, 21204 United States, Massachusetts Internal Medicine & Cardiology Associates Fall River, Massachusetts, United States, 02720 Prima CARE Fall River, Massachusetts, United States, 02720 United States, Virginia Carilion Clinic Christiansburg, Virginia, United States, 24073 收起 << | |
| NCT00000464 | Arrhythmia Ca... 展开 >>rdiovascular Diseases Heart Arrest Heart Diseases Myocardial Infarction Ventricular Fibrillation 收起 << | Phase 3 | Completed | - | - |
| NCT00000518 | Arrhythmia Ca... 展开 >>rdiovascular Diseases Death, Sudden, Cardiac Heart Diseases Tachycardia, Ventricular Ventricular Arrhythmia Ventricular Fibrillation 收起 << | Phase 3 | Completed | - | - |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
3.16mL 0.63mL 0.32mL |
15.78mL 3.16mL 1.58mL |
31.56mL 6.31mL 3.16mL |
| 参考文献 |
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