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Saxagliptin hydrochloride

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Chemical Structure| 709031-78-7 同义名 : BMS-477118 hydrochloride;Saxagliptin (hydrochloride);BMS-477118
CAS号 : 709031-78-7
货号 : A130556
分子式 : C18H26ClN3O2
纯度 : 98%
分子量 : 351.871
MDL号 : MFCD22572334
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(341.03 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(284.2 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Saxagliptin hydrochloride (BMS-477118 hydrochloride) is a potent, selective, reversible, and orally active inhibitor of dipeptidyl peptidase-4 (DPP-4), with a Ki ranging from 0.6 to 1.3 nM[1].[2].[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.84mL

0.57mL

0.28mL

14.21mL

2.84mL

1.42mL

28.42mL

5.68mL

2.84mL
参考文献

[1]Chun-Jun Li, et al. Saxagliptin Induces β-Cell Proliferation through Increasing Stromal Cell-Derived Factor-1α In Vivo and In Vitro. Front Endocrinol (Lausanne). 2017 Nov 27;8:326.

[2]Darshan J Dave. Saxagliptin: A dipeptidyl peptidase-4 inhibitor in the treatment of type 2 diabetes mellitus. J Pharmacol Pharmacother. 2011 Oct;2(4):230-5.

[3]Carolyn F Deacon, et al. Saxagliptin: a new dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes. Adv Ther. 2009 May;26(5):488-99.