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Salidroside

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Chemical Structure| 10338-51-9 同义名 : Rhodioloside
CAS号 : 10338-51-9
货号 : A130275
分子式 : C14H20O7
纯度 : 98%
分子量 : 300.3
MDL号 : MFCD00210553
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(349.65 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(333 mM)
动物实验配方：
生物活性
描述 Salidroside is an inhibitor of prolyl endopeptidase. Salidroside (100 μM) inhibits prolyl endopeptidase (PEP) activity (10.6±1.9%)[3]. Salidroside suppressed reactive oxygen species production and restore mitochondrial membrane potential (ΔΨm) [4]. Moreover, salidroside protects against NAFLD(nonalcoholic fatty liver disease ) by improving hepatic lipid metabolism and NLRP3 inflammasome activation[5]. Salidroside (100 mg/kg/day) shows strong glucose lowering effect on db/db mice[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.33mL

0.67mL

0.33mL

16.65mL

3.33mL

1.67mL

33.30mL

6.66mL

3.33mL
参考文献

[1]Hu X, Lin S, et al. A preliminary study: the anti-proliferation effect of salidroside on different human cancer cell lines. Cell Biol Toxicol. 2010 Dec;26(6):499-507.

[2]Yu S, Shen Y, et al. Involvement of ERK1/2 pathway in neuroprotection by salidroside against hydrogen peroxide-induced apoptotic cell death. J Mol Neurosci. 2010 Mar;40(3):321-31.

[3]Fan W, Tezuka Y, Ni KM, Kadota S. Prolyl endopeptidase inhibitors from the underground part of Rhodiola sachalinensis. Chem Pharm Bull (Tokyo). 2001 Apr;49(4):396-401. doi: 10.1248/cpb.49.396. PMID: 11310664.

[4]Ju L, Wen X, Wang C, Wei Y, Peng Y, Ding Y, Feng L, Shu L. Salidroside, A Natural Antioxidant, Improves β-Cell Survival and Function via Activating AMPK Pathway. Front Pharmacol. 2017 Oct 18;8:749. doi: 10.3389/fphar.2017.00749. PMID: 29093682; PMCID: PMC5651268.

[5]Zheng T, Yang X, Li W, Wang Q, Chen L, Wu D, Bian F, Xing S, Jin S. Salidroside Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease via AMPK-Dependent TXNIP/NLRP3 Pathway. Oxid Med Cell Longev. 2018 Jul 22;2018:8597897. doi: 10.1155/2018/8597897. PMID: 30140371; PMCID: PMC6081551.

[6]Zheng T, Yang X, Wu D, Xing S, Bian F, Li W, Chi J, Bai X, Wu G, Chen X, Zhang Y, Jin S. Salidroside ameliorates insulin resistance through activation of a mitochondria-associated AMPK/PI3K/Akt/GSK3β pathway. Br J Pharmacol. 2015 Jul;172(13):3284-301. doi: 10.1111/bph.13120. Epub 2015 Apr 24. PMID: 25754463; PMCID: PMC4500366.