产品说明书
Peramivir Trihydrate
 |
同义名 : | RWJ 270201 trihydrate;BCX 1812 trihydrate;S-021812;RWJ-270201;BCX-1812 |
| CAS号 : | 1041434-82-5 | |
| 货号 : | A130237 | |
| 分子式 : | C15H34N4O7 | |
| 纯度 : | 98% | |
| 分子量 : | 382.453 | |
| MDL号 : | - | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
H2O: 5 mg/mL(13.07 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Peramivir trihydrate (RWJ-270201, BCX-1812) is a highly potent, selective and orally active influenza virus neuraminidase (NA) inhibitor, with IC50 values ranging from 0.9 to 4.3 nM for nine NA subtypes. RWJ-270201 has efficacy comparable to or better than earlier NA inhibitors against a wide range of influenza A and B isolates, including recently emerged and avian strains, both in vitro and in a lethal murine model of influenza[3]. Peramivir is effective against a variety of influenza A and B subtypes and has a lower half-maximal inhibitory concentration compared to other NAIs in in vitro studies. The long half-life of peramivir allows for once-daily dosing. The drug is eliminated primarily by the kidneys, warranting dose adjustments in patients with renal dysfunction[4]. Peramivir is administered as a single-dose via the intravenous route providing a valuable therapeutic alternative for critically ill patients or those unable to tolerate other administration routes[5]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.61mL 0.52mL 0.26mL |
13.07mL 2.61mL 1.31mL |
26.15mL 5.23mL 2.61mL |
| 参考文献 |
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