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AZD5153 6-Hydroxy-2-naphthoic acid

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Chemical Structure| 1869912-40-2 同义名 : AZD5153 HNT salt
CAS号 : 1869912-40-2
货号 : A129684
分子式 : C36H41N7O6
纯度 : 99%+
分子量 : 667.754
MDL号 : MFCD31382122
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(157.24 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • BET

    FL-BRD4, IC50:5 nM
描述 AZD5153 shows a significant increase in efficacy for displacing the entire BRD4 compared to BD1, with IC50 values of 5.0 nM for full-length BRD4 and 1.6 μM for BD1. In U2OS cells, AZD5153 effectively disrupts BRD4 foci, reflected by an IC50 of 1.7 nM. Additionally, AZD5153 consistently lowers MYC protein expression in various cell lines, regardless of their response to AZD5153 treatment[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.50mL

0.30mL

0.15mL

7.49mL

1.50mL

0.75mL

14.98mL

3.00mL

1.50mL
参考文献

[1]Rhyasen GW, et al. AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies. Mol Cancer Ther. 2016 Nov;15(11):2563-2574.