产品说明书
Sulbenicillin disodium
 |
同义名 : | Sulbenicillin sodium;Sulfocillin;Disodium sulfobenzylpenicillin;Disodium sulbenicillin;alpha-Sulfobenzylpenicillin disodium;Sulfobenzylpenicillin |
| CAS号 : | 28002-18-8 | |
| 货号 : | A128480 | |
| 分子式 : | C16H16N2Na2O7S2 | |
| 纯度 : | 95% | |
| 分子量 : | 458.417 | |
| MDL号 : | MFCD01682086 | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
H2O: 250 mg/mL(545.35 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Sulbenicillin disodium is the disodium salt of Sulbenicillin. Sulbenicillin is a Penicillin antibiotic with antibacterial activity against a number of mucoid and non-mucoid strains of Pseudomonas aeruginosa[1]. The regrowth of test strains after removal of the drugs was suppressed markedly, even when they were exposed to sulbenicillin plus dibekacin at a subinhibitory concentration of individual drugs. Sulbenicillin caused elongation of the bacterial cells. The combined use of sulbenicillin and dibekacin caused elongation of bacilli and severe destruction of the inner and outer membranes of the cell wall[2]. The antibacterial spectra of sulbenicillin and carbenicillin were similar but the MIC values were lower for sulbenicillin against most of the bacterial strains tested. The serum concentrations obtained after administration of 5 g sulbenicillin were significantly higher than those obtained after 5 g carbenicillin although no significant differences in serum half-lives were observed[3]. Ssulbenicillin showed better anti-microbial activity than carbenicillin in almost all the tests run. Sulbenicillin appears to have a somewhat lower activity than piperacillin and cefotaxime[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.18mL 0.44mL 0.22mL |
10.91mL 2.18mL 1.09mL |
21.81mL 4.36mL 2.18mL |
| 参考文献 |
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