D-(+)-Galactosamine HCI

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Chemical Structure| 1772-03-8 同义名 : D-氨基半乳糖盐酸盐;D-半乳糖胺盐酸盐 ;D-Galactosamine (hydrochloride);D-Galactosamine hydrochloride;D-(+)-Galactosamine
CAS号 : 1772-03-8
货号 : A128462
分子式 : C6H14ClNO5
纯度 : 98%
分子量 : 215.632
MDL号 : -
存储条件:

Pure form Keep in dark place,Sealed in dry,Room Temperature

In solvent -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 25 mg/mL(115.94 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 100 mg/mL(463.75 mM),配合低频超声助溶

动物实验配方:
生物活性
描述 D(+)-Galactosamine hydrochloride, a well-known experimental toxin, primarily inflicts liver damage through free radical production and UTP nucleotide depletion. Intoxication with D(+)-Galactosamine hydrochloride also leads to renal dysfunction, often culminating in renal failure associated with severe liver damage. The combination of Lipopolysaccharide and D(+)-Galactosamine-induced acute liver injury serves as an established animal model for fulminant hepatic failure[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.64mL

0.93mL

0.46mL

23.19mL

4.64mL

2.32mL

46.38mL

9.28mL

4.64mL

参考文献

[1]Li Y, et al. Inhibition of PI3K/AKt/mTOR signaling pathway protects against d-galactosamine/lipopolysaccharide-induced acute liver failure by chaperone-mediated autophagy in rats. Biomed Pharmacother. 2017 Aug;92:544-553.

[2]Liu Y, et al. AMSC-derived exosomes alleviate lipopolysaccharide/d-galactosamine-induced acute liver failure by miR-17-mediated reduction of TXNIP/NLRP3 inflammasome activation in macrophages. EBioMedicine. 2018 Oct;36:140-150.

[3]Siendones E, et al. PGE1 abolishes the mitochondrial-independent cell death pathway induced by D-galactosamine in primary culture of rat hepatocytes. J Gastroenterol Hepatol. 2005 Jan;20(1):108-16.