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FPR-A14

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Chemical Structure| 329691-12-5 同义名 : -
CAS号 : 329691-12-5
货号 : A1282528
分子式 : C23H20N2O5
纯度 : 99%+
分子量 : 404.415
MDL号 : MFCD01065721
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(296.72 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 FPR-A14 is a potent FPR agonist. FPR-A14 induces cell differentiation[1][2]. FPR-A14 activates Ca2+ release from human neutrophils with an EC50 value of 630 nM. FPR-A14 is a neutrophil chemotaxis inducer that dose-dependently induces neutrophil migration with an EC50 value of 42 nM[1] . In mouse neuroblastoma N2a cells, FPR-A14 significantly increased the cell differentiation rate in the concentration range of 1-10 μM for 48 h. The concentrations with responses were 4 μM (32. 0%), 6 μM (64. 9%), 8 μM (89. 1%) and 10 μM (93. 3%), respectively. At a concentration of 100 μM, FPRa14 produced similar effects in IMR-32 and SH-SY5Y cells[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.47mL

0.49mL

0.25mL

12.36mL

2.47mL

1.24mL

24.73mL

4.95mL

2.47mL
参考文献

[1]Igor A Schepetkin, et al. High-throughput screening for small-molecule activators of neutrophils: identification of novel N-formyl peptide receptor agonists. Mol Pharmacol. 2007 Apr;71(4):1061-74.

[2]Peter J G Cussell, et al. The formyl peptide receptor agonist FPRa14 induces differentiation of Neuro2a mouse neuroblastoma cells into multiple distinct morphologies which can be specifically. inhibited with FPR antagonists and FPR knockdown using siRNA. PLoS One. 2019 Jun 6;14(6):e0217815.