RL-0070933

产品说明书

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Chemical Structure| 301326-41-0 同义名 : -
CAS号 : 301326-41-0
货号 : A1281358
分子式 : C20H16N2O2
纯度 : 99%+
分子量 : 316.353
MDL号 : N/A
存储条件：

Pure form Sealed in dry,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 RL-0070933 is a potent Smo cilial modulator with an EC50 value of 0.02 µM. It modulates the translocation and/or accumulation of Smoothened to the primary cilia through the hedgehog signaling pathway [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.16mL

0.63mL

0.32mL

15.81mL

3.16mL

1.58mL

31.61mL

6.32mL

3.16mL
参考文献

[1]Li S, et al. Specific inhibition of histone deacetylase 8 reduces gene expression and production of proinflammatory cytokines in vitro and in vivo. J Biol Chem. 2015 Jan 23;290(4):2368-78.