产品说明书
TRULI
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同义名 : | Lats-IN-1;LATS Inhibitor 1;TRULI, Lats-IN-1, LATS Inhibitor 1 |
| CAS号 : | 1424635-83-5 | |
| 货号 : | A1280924 | |
| 分子式 : | C18H14N4OS | |
| 纯度 : | 99%+ | |
| 分子量 : | 334.395 | |
| MDL号 : | MFCD33402276 | |
| 存储条件： |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 50 mg/mL(149.52 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | LATS1 and LATS2 (LATS) have emerged as central regulators of cell fate, by modulating the functions of numerous oncogenic or tumor suppressive effectors, including the canonical Hippo effectors YAP/TAZ[1]. TRULI is an inhibitor of both Lats 1 and Lats 2. It blocks the final kinases in Hippo signaling pathwayLats1 and Lats2, and led decrease of Yap phosphorylation. Thus elicits proliferation of several cell types that are ordinarily post-mitotic and aids regeneration in mammals[2]. In confluent cells treated with TRULI at 10μM for 24h, protein blotting revealed that the Hippo signaling cascade was intact through the phosphorylation of the activation loops of Lats1 and Larts2. However, the phosphorylation of Yap was decreased at residue S127, which is a key site of Lats phosphorylation[3]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.99mL 0.60mL 0.30mL |
14.95mL 2.99mL 1.50mL |
29.90mL 5.98mL 2.99mL |
| 参考文献 |
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