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TPE-MI

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Chemical Structure| 1245606-71-6 同义名 : Tetraphenylethene maleimide
CAS号 : 1245606-71-6
货号 : A1280612
分子式 : C31H23NO2
纯度 : 98%+
分子量 : 441.52
MDL号 : MFCD28901372
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 45 mg/mL(101.92 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 TPE-MI (Tetraphenylethene maleimide) serves as a thiol probe that measures the load of unfolded proteins and monitors proteostasis in cells. It can indicate proteostasis imbalances in induced pluripotent stem cell models of Huntington's disease and in cells transfected with mutant Huntington exon 1 before aggregates become visible. TPE-MI also identifies protein damage in studies involving the malaria parasite Plasmodium falciparum[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.26mL

0.45mL

0.23mL

11.32mL

2.26mL

1.13mL

22.65mL

4.53mL

2.26mL
参考文献

[1]Chen MZ, et al. A thiol probe for measuring unfolded protein load and proteostasis in cells. Nat Commun. 2017;8(1):474. Published 2017 Sep 7.

[2]Hu Q, et al. In Situ Monitored Vortex Fluidic-Mediated Protein Refolding/Unfolding Using an Aggregation-Induced Emission Bioprobe. Molecules. 2021;26(14):4273. Published 2021 Jul 14.