产品说明书

SC-26196

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Chemical Structure| 218136-59-5 同义名 : α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile
CAS号 : 218136-59-5
货号 : A1275278
分子式 : C27H29N5
纯度 : 99%
分子量 : 423.553
MDL号 : MFCD11226148
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 4 mg/mL(9.44 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 SC-26196 is a potent, orally active inhibitor of Delta6 desaturase (D6D, FADS2). In a rat liver microsome assay, SC-26196 showed an IC50 value of 0.2 µM. SC-26196 has anti-inflammatory properties]1].At a concentration of 200 nM, with treatment for 144 hours, SC-26196 inhibited the proliferation of peripheral blood mononuclear cells (PBMCs), but not Jurkat cells[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.36mL

0.47mL

0.24mL

11.80mL

2.36mL

1.18mL

23.61mL

4.72mL

2.36mL
参考文献

[1]Obukowicz MG, et al. Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice. J Pharmacol Exp Ther. 1998 Oct;287(1):157-66.

[2]Sibbons CM, et al. Polyunsaturated Fatty Acid Biosynthesis Involving Δ8 Desaturation and Differential DNA Methylation of FADS2 Regulates Proliferation of Human Peripheral Blood Mononuclear Cells. Front Immunol. 2018 Mar 5;9:432.

[3]Hargrave-Barnes KM, et al. Conjugated linoleic acid-induced fat loss dependence on Delta6-desaturase or cyclooxygenase. Obesity (Silver Spring). 2008 Oct;16(10):2245-52.