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Oxcarbazepine

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Chemical Structure| 28721-07-5 同义名 : GP 47680
CAS号 : 28721-07-5
货号 : A127391
分子式 : C15H12N2O2
纯度 : 98%
分子量 : 252.268
MDL号 : MFCD00865307
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(198.2 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

IP 2% DMSO+2% Tween80+40% PEG300+water 2 mg/mL clear

PO 0.5% CMC-Na 40 mg/mL suspension

生物活性
靶点

  • Sodium Channel

    sodium channel, IC50:160 μM
描述 Oxcarbazepine inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of Na+ into rat brain synaptosomes with IC50 about 100 μM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.96mL

0.79mL

0.40mL

19.82mL

3.96mL

1.98mL

39.64mL

7.93mL

3.96mL
参考文献

[1]Zhou M, Chen N, et al. Oxcarbazepine for neuropathic pain. Cochrane Database Syst Rev. 2013 Mar 28;(3):CD007963.

[2]May TW, Korn-Merker E, et al. Clinical pharmacokinetics of oxcarbazepine. Clin Pharmacokinet. 2003;42(12):1023-42.