Oxypeucedanin

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Chemical Structure| 737-52-0 同义名 : -
CAS号 : 737-52-0
货号 : A127326
分子式 : C16H14O5
纯度 : 99%+
分子量 : 286.279
MDL号 : MFCD00600495
存储条件：

Pure form Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(174.65 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Oxypeucedanin is a furocoumarin derivative isolated from Angelica dahurica and a selective open-channel blocker. Oxypeucedanin inhibited the hKv1.5 current in a concentration-dependent manner, with an IC(50) value of 76 nM, while it had no effect on human eag-related gene (HERG) current. Additionally, oxypeucedanin prolonged the APD (action potential duration) of rat atrial and ventricular muscles in a dose-dependent manner[3]. Oxypeucedanin (OPD) effectively inhibited the growth of SK-Hep-1 cells. Flow cytometric analysis revealed that OPD was able to induce G2/M phase cell cycle arrest in cells. In addition, the combination of OPD with gemcitabine showed synergistic growth-inhibitory activity in SK-Hep-1 cells[4]. Treatment with oxypeucedanin inhibited cell growth and induced cell death in DU145 cells. Furthermore, oxypeucedanin-induced cell growth inhibition was associated with an increase in G2-M arrest in cell cycle progression in DU145 cells in a dose and time-dependent manner[5]. Microsomal incubation with oxypeucedanin induced a time-, concentration-, and NADPH-dependent inhibition of CYPs2B6 and 2D6 with kinetic values of KI/kinact 1.82 µM/0.07 min-1 (CYP2B6) and 8.47 µM/0.044 min-1 (CYP2D6), respectively[6]. OPD reverse P-gp-mediated drug transport via inhibition of P-gp activity and P-gp protein expression as well as downregulation of P-gp mRNA level[7].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.49mL

0.70mL

0.35mL

17.47mL

3.49mL

1.75mL

34.93mL

6.99mL

3.49mL
参考文献

[1]Choi JS, Shin HY, et al. Effects of oxypeucedanin on global gene expression and MAPK signaling pathway in mouse neuroblastoma Neuro-2A cells. Planta Med. 2011 Sep;77(13):1512-8.

[2]Kang TJ, Lee SY, et al. Anti-tumor activity of oxypeucedanin from Ostericum koreanum against human prostate carcinoma DU145 cells. Acta Oncol. 2009;48(6):895-900.

[3]Eun JS, Park JA, Choi BH, Cho SK, Kim DK, Kwak YG. Effects of oxypeucedanin on hKv1.5 and action potential duration. Biol Pharm Bull. 2005 Apr;28(4):657-60

[4]Park SH, Hong JY, Park HJ, Lee SK. The Antiproliferative Activity of Oxypeucedanin via Induction of G2/M Phase Cell Cycle Arrest and p53-Dependent MDM2/p21 Expression in Human Hepatoma Cells. Molecules. 2020 Jan 23;25(3):501

[5]Kang TJ, Lee SY, Singh RP, Agarwal R, Yim DS. Anti-tumor activity of oxypeucedanin from Ostericum koreanum against human prostate carcinoma DU145 cells. Acta Oncol. 2009;48(6):895-900

[6]Zhang K, Li Y, Fu Y, Cui T, Wang Q, Mao X, Peng Y, Zheng J. Oxypeucedanin is a mechanism-based inactivator of CYP2B6 and CYP2D6. Curr Drug Metab. 2021 Jun 29

[7]Dong W, Liao ZG, Zhao GW, Guan XJ, Zhang J, Liang XL, Yang M. Reversal Effect of Oxypeucedanin on P-glycoprotein-mediated Drug Transport. Molecules. 2018 Jul 24;23(8):1841