Polymyxin B Sulfate

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Chemical Structure| 1405-20-5 同义名 : Mastimyxin;Polymyxin B (sulfate);KS-1428;Poly-RX;PMB;Aerosporin;Polymyxin B sulphate
CAS号 : 1405-20-5
货号 : A126472
分子式 : -
纯度 : ≥6500IU/mg
分子量 : 0
MDL号 : MFCD00270609
存储条件：

Pure form Keep in dark place,Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 15 mg/mL，配合低频超声助溶
动物实验配方：
生物活性
描述 Dimethylcurcumin (ASC-J9) is an androgen receptor degradation enhancer that effectively suppresses castration resistant prostate cancer cell proliferation and invasion. Intraperitoneal injection of ASC-J9 into AR-polyQ transgenic SBMA (spinal and bulbar muscular atrophy) mice markedly improved disease symptoms, as seen by a reduction in muscular atrophy. ASC-J9 treatment ameliorated SBMA symptoms by decreasing AR-97Q aggregation and increasing VEGF164 expression with little change of serum testosterone. Moreover, mice treated with ASC-J9 retained normal sexual function and fertility[3]. Androgen receptor (AR) facilitated EAM (Experimental autoimmune myocarditis) development, and targeting AR with ASC-J9 attenuated cardiac injury and dysfunction by inhibiting macrophages polarization towards M1 macrophages[4]. Dimethylcurcumin (ASC-J9) (75 mg/kg, i.p.) degrades both fAR and AR3 in the xenografted tumors in vivo, and SC-J9-treated tumors has significantly decreased Ki67-positive cells[5].
参考文献

[1]Rolin O, Muse SJ, et al. Enzymatic modification of lipid A by ArnT protects Bordetella bronchiseptica against cationic peptides and is required for transmission. Infect Immun. 2014 Feb;82(2):491-9.

[2]Pye CC, Yu AA, et al. Evaluation of biofilm production by Pseudomonas aeruginosa from canine ears and the impact of biofilm on antimicrobial susceptibility in vitro. Vet Dermatol. 2013 Aug;24(4):446-9, e98-9.

[3]Yang Z, Chang YJ, Yu IC, et al. ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor. Nat Med. 2007;13(3):348–353

[4]Ma W, Wang Y, Lu S, Yan L, Hu F, Wang Z. Targeting androgen receptor with ASC-J9 attenuates cardiac injury and dysfunction in experimental autoimmune myocarditis by reducing M1-like macrophage. Biochem Biophys Res Commun. 2017;485(4):746–752

[5]Yamashita S, Lai KP, Chuang KL, et al. ASC-J9 suppresses castration-resistant prostate cancer growth through degradation of full-length and splice variant androgen receptors. Neoplasia. 2012;14(1):74–83