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MAC-545496

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Chemical Structure| 838810-96-1 同义名 : -
CAS号 : 838810-96-1
货号 : A1263957
分子式 : C18H18ClN5O3S
纯度 : 99%+
分子量 : 419.885
MDL号 : MFCD05848166
存储条件:

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 250 mg/mL(595.4 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 GraR (glycopeptide-resistance-associated protein R), also known as ApsR (antimicrobial-peptide sensor protein R) is a response regulator protein of a multicomponent regulatory system including the sensor kinase GraS, a signal transduction accessory protein GraX that is associated with the ABC transporter VraFG. GraR is a regulator that responds to cell-envelope stress and is an important virulence factor and determinant of antibiotic resistance. MAC-545496 is a nanomolar inhibitor of GraR. MAC-545496 reverses β-lactam resistance in the community-acquired methicillin-resistant strains (MRSA) USA300 strain. MAC-545496 could also serve as an antivirulence agent alone; it attenuates MRSA virulence in Galleria mellonella larvae. MAC-545496 (~0.5 μg/mL) inhibits biofilm formation and abrogates intracellular survival in macrophages[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.38mL

0.48mL

0.24mL

11.91mL

2.38mL

1.19mL

23.82mL

4.76mL

2.38mL

参考文献

[1]El-Halfawy OM, Czarny TL, Flannagan RS, et al. Discovery of an antivirulence compound that reverses β-lactam resistance in MRSA. Nat Chem Biol. 2020;16(2):143-149.