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FAPI-4

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Chemical Structure| 2374782-02-0 同义名 : -
CAS号 : 2374782-02-0
货号 : A1263556
分子式 : C40H54F2N10O10
纯度 : 98%
分子量 : 872.915
MDL号 : MFCD32067986
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(120.29 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 FAPI-4 is a highly effective inhibitor of fibroblast activation protein (FAP), specifically targeting FAP. FAPI-4 holds potential for application in cancer research. Additionally, 68Ga-FAPI-4 PET/CT emerges as a promising novel diagnostic tool for visualizing diverse cancer types, characterized by favorable tumor-to-background contrast ratios[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.15mL

0.23mL

0.11mL

5.73mL

1.15mL

0.57mL

11.46mL

2.29mL

1.15mL
参考文献

[1]Giesel FL, et al. 68Ga-FAPI PET/CT: Biodistribution and Preliminary Dosimetry Estimate of 2 DOTA-Containing FAP-Targeting Agents in Patients with Various Cancers. J Nucl Med. 2019 Mar;60(3):386-392.

[2]Anastasia Loktev, et al. Development of Fibroblast Activation Protein-Targeted Radiotracers with Improved Tumor Retention. J Nucl Med. 2019 Oct;60(10):1421-1429.