产品说明书
NS-3-008 HCl
 |
同义名 : | NS-3-008 hydrochloride |
| CAS号 : | 1172854-54-4 | |
| 货号 : | A1262968 | |
| 分子式 : | C14H24ClN3 | |
| 纯度 : | 99%+ | |
| 分子量 : | 269.813 | |
| MDL号 : | MFCD03931143 | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 120 mg/mL(444.75 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 120 mg/mL(444.75 mM)，配合低频超声助溶 |
|
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | G0/G1 switch 2 (G0s2) may aggravate renal dysfunction in the context of CKD (chronic kidney disease) through mechanisms involving increased renal expression of the Clock gene making G0s2 a promising therapeutic target in the treatment of CKD. NS-3-008 HCl is an orally active G0s2 transcriptional inhibitor with an IC50 of 2.25 μM. Treatment of wild-type 5/6Nx mice with NS-3-008 (5 mg/kg, P.O.) resulted in decreased levels of G0s2 and Ccl2 mRNA in the kidneys. Furthermore, the phosphorylation of Stat5 and p65 protein was decreased in wild-type 5/6Nx mice treated with NS-3-008, and serum urea nitrogen (SUN) concentrations and renal caspase 3/7 activity decreased as well. Finally, the F4/80-positive area and F4/80 protein levels were decreased in 5/6Nx mice treated with NS-3-008[1]. | ||
| 作用机制 | NS-3-008 bound to Hsd17b4[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
3.71mL 0.74mL 0.37mL |
18.53mL 3.71mL 1.85mL |
37.06mL 7.41mL 3.71mL |
| 参考文献 |
|---|