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NNMTi

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Chemical Structure| 42464-96-0 同义名 : -
CAS号 : 42464-96-0
货号 : A1258379
分子式 : C10H11IN2
纯度 : 97%
分子量 : 286.112
MDL号 : MFCD22125886
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 20 mg/mL(69.9 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 2 mg/mL(6.99 mM)，配合低频超声，并水浴加热至45℃助溶
动物实验配方：
生物活性
描述 NNMTi is a potent inhibitor of nicotinamide N-methyltransferase (NNMT), with an IC50 of 1.2 μM, selectively targeting the substrate-binding site residues of NNMT[2]. NNMTi enhances myoblast differentiation in vitro and improves the fusion and regenerative capabilities of muscle stem cells (muSCs) in aged mice[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.50mL

0.70mL

0.35mL

17.48mL

3.50mL

1.75mL

34.95mL

6.99mL

3.50mL
参考文献

[1]Harshini Neelakantan, et al. Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochem Pharmacol. 2019 May;163:481-492.

[2]Harshini Neelakantan, et al. Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase. J Med Chem