产品说明书

ML188

Print
Chemical Structure| 1417700-13-0 同义名 : -
CAS号 : 1417700-13-0
货号 : A1257467
分子式 : C26H31N3O3
纯度 : 99%+
分子量 : 433.543
MDL号 : MFCD32693920
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(576.64 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 The coronavirus 3 chymotrypsin-like protease (3CL(pro)) is a validated target in the design of potential anticoronavirus inhibitors. The compound ML188, also termed 16R, works as an inhibitor of the Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) 3CL(pro)[1]. ML188 represents the first true non-covalent 3CLpro inhibitor with modest molecular weight (MW) and good inhibitory activity below 2 μM[2]. ML188 inhibits SARS-CoV-2 Mpro at 2.5µM, which is more potent than against SAR-CoV-1 Mpro[3]. ML188 yields an antiviral EC50 values ranging from 12.9 to 13.4μM in mock-infected and SARS-CoV infected cells.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.31mL

0.46mL

0.23mL

11.53mL

2.31mL

1.15mL

23.07mL

4.61mL

2.31mL
参考文献

[1]Michael Berry,et al. Human coronavirus OC43 3CL protease and the potential of ML188 as a broad-spectrum lead compound: homology modelling and molecular dynamic studies. BMC Struct Biol. 2015 Apr 28;15:8. doi: 10.1186/s12900-015-0035-3.

[2]Jon Jacobs,et al. Discovery of non-covalent inhibitors of the SARS main proteinase 3Clpro. National Center for Biotechnology Information (US); 2010–.2010 Oct 30

[3]Gordon J Lockbaum,et al. Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188. Viruses. 2021 Jan 25;13(2):174.