产品说明书
Kaempferide
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同义名 : | Kaempferol 4'-O-methyl ether;NSC 407294;3,5,7-Trihydroxy-4′-methoxyflavone;Kaempferol 4'-methyl ether;4'-O-Methylkaempferol;4'-Methylkaempferol |
| CAS号 : | 491-54-3 | |
| 货号 : | A125385 | |
| 分子式 : | C16H12O6 | |
| 纯度 : | 99%+ | |
| 分子量 : | 300.263 | |
| MDL号 : | MFCD00016771 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 18 mg/mL(59.95 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Kaempferide (KF) is an O-methylated flavonol, a natural plant extract, which is often found in Kaempferia galanga. It has a variety of effects including anti-carcinogenic, anti-inflammatory, anti-oxidant, anti-bacterial and anti-viral properties. In the mice with titanium particle induced calvarial osteolysis, the low dose of KF mildly reduced the resorption pits while in the high dose group, fewer scattered pits were observed on the surface of calvarium. Histological examination showed fewer osteoclasts formation in the KF group. In mouse bone marrow macrophages (BMMs) and RAW264.7 cells, KF significantly inhibited the osteoclast formation and bone resorption at 12.5 μM[3]. KF could prevent cognitive decline in mice induced by Aβ1-42 as assessed by the locomotor activity test, Y-maze test, and Morris water maze test. Furthermore, the activities of superoxide dismutase and malondialdehyde in the hippocampus and cerebral cortex were elevated by KF administration[4]. Kaempferide was oxidized by human liver microsomes to kaempferol, with K(m) values of 17.8 mM. These oxidations were catalyzed mainly by CYP1A2 but also by CYP2C9[5]. Kaempferide remarkably improved cardiac function, alleviated myocardial injury via a decrease in myocardial enzyme levels, and attenuated myocardial infarct size in a dose-dependent manner. In addition, preconditioning treatment with Kae was found to significantly decrease serum TNF-α, IL-6, C-reactive protein (CRP), MDA, and ROS levels, while it was found to increase serum levels of SOD[6]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.33mL 0.67mL 0.33mL |
16.65mL 3.33mL 1.67mL |
33.30mL 6.66mL 3.33mL |
| 参考文献 |
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