产品说明书
Ubiquitination-IN-1
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同义名 : | - |
| CAS号 : | 1819330-15-8 | |
| 货号 : | A1251869 | |
| 分子式 : | C21H14F3N3O2S | |
| 纯度 : | 99%+ | |
| 分子量 : | 429.415 | |
| MDL号 : | MFCD31617017 | |
| 存储条件： |
粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 85 mg/mL(197.94 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Ubiquitination-IN-1 is an inhibitor of ubiquitination and the Cks1-Skp2 protein-protein interaction (IC50=0.17 μM). It elevates levels of p27 and holds promise for treating diseases by impeding the degradation of tumor suppressors[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.33mL 0.47mL 0.23mL |
11.64mL 2.33mL 1.16mL |
23.29mL 4.66mL 2.33mL |
| 参考文献 |
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[1]David Carroll, et al.Quinoline derivatives useful as ubiquitination inhibitors. WO2016025779A1. |