产品说明书

CU-T12-9

Print
Chemical Structure| 1821387-73-8 同义名 : -
CAS号 : 1821387-73-8
货号 : A1251827
分子式 : C17H13F3N4O2
纯度 : 99%+
分子量 : 362.306
MDL号 : MFCD30182292
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(690.02 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 CU-T12-9 is a specific TLR1/2 agonist with an EC50 of 52.9 nM in the HEK-Blue hTLR2 SEAP assay. CU-T12-9 activates both the innate and adaptive immune systems. CU-T12-9 directly targets TLR1/2, initiating downstream signaling. By binding to TLR1 and TLR2, CU-T12-9 promotes the formation of TLR1/2 heterodimeric complexes (without acting on TLR2/6), thereby activating downstream signaling. CU-T12-9 causes an increase in the downstream effectors TNF-α, IL-10 and iNOS through NF-κB mediation. CU-T12-9 upregulates the mRNA levels of TLR1, TLR2, TNF, IL-10, and iNOS. In the concentration range of 0.1-10 μM, CU-T12-9 can activate TLR1 mRNA and iNOS mRNA after 24 hours of treatment on Raw 264.7 cells. In the concentration range of 0.1-10 μM, CU-T12-9 can activate TLR2 and IL-10 mRNA in Raw 264.7 cells after 2 hours of action, and activate TNF mRNA in Raw 264.7 cells after 8 hours of action[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.76mL

0.55mL

0.28mL

13.80mL

2.76mL

1.38mL

27.60mL

5.52mL

2.76mL
参考文献

[1]Cheng K, et al. Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists. Sci Adv. 2015;1(3). pii: e1400139.