产品说明书

IT-901

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Chemical Structure| 1584121-99-2 同义名 : -
CAS号 : 1584121-99-2
货号 : A1249394
分子式 : C17H14N2O4S
纯度 : 98%+
分子量 : 342.369
MDL号 : MFCD30729129
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 12 mg/mL(35.05 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 IT-901 is an orally active and potent inhibitor of the NF-κB subunit c-Rel, with IC50 values of 0.1 µM for NF-κB DNA binding and 3 μM for c-Rel DNA binding, respectively. As a bioactive naphthalenethiobarbiturate derivative, IT-901 holds promise for treating human lymphoid tumors and alleviating graft-versus-host disease (GVHD) [1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.92mL

0.58mL

0.29mL

14.60mL

2.92mL

1.46mL

29.21mL

5.84mL

2.92mL
参考文献

[1]Shono Y, et al. Characterization of a c-Rel Inhibitor That Mediates Anticancer Properties in HematologicMalignancies by Blocking NF-κB-Controlled Oxidative Stress Responses. Cancer Res. 2016 Jan 15;76(2):377-89.

[2]Vaisitti T, et al. Targeting metabolism and survival in chronic lymphocytic leukemia and Richter syndrome cellsby a novel NF-κB inhibitor. Haematologica. 2017 Nov;102(11):1878-1889.