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5-HT2B antagonist-1

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Chemical Structure| 393129-91-4 同义名 : -
CAS号 : 393129-91-4
货号 : A1234856
分子式 : C22H28N4O2S2
纯度 : 99%+
分子量 : 444.613
MDL号 : MFCD02655070
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(78.72 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 12 mg/mL(26.99 mM)，配合低频超声，并水浴加热至45℃助溶
动物实验配方：
生物活性
描述 5-HT2B antagonist-1, an orally active antagonist with an IC50 value of 33.4 nM, is applicable in diseases involving 5-HT2B receptor signaling, such as hepatocellular carcinoma, cardiovascular disease, or gastrointestinal disease[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.25mL

0.45mL

0.22mL

11.25mL

2.25mL

1.12mL

22.49mL

4.50mL

2.25mL
参考文献

[1]Xiang Ma, et al. Synthesis and in vitro evaluation of 2,4-diamino-1,3,5-triazine derivatives as neuronal voltage-gated sodium channel blockers. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5644

[2]Yu Zhou, et al. Structure-Based Discovery of Novel and Selective 5-Hydroxytryptamine 2B Receptor Antagonists for the Treatment of Irritable Bowel Syndrome. J Med Chem. 2016 Jan 28;59(2):707-20.

[3]Huang Niu, et al. 5-HT2B Antagonists. WO2015158214