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Asaraldehyde

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Chemical Structure| 4460-86-0 同义名 : 2,4,5-三甲氧基苯甲醛 ;Asaronaldehyde;2,4,5-trimethoxy-Benzaldehyde
CAS号 : 4460-86-0
货号 : A123250
分子式 : C10H12O4
纯度 : 98%
分子量 : 196.2
MDL号 : -
存储条件：

粉末 Keep in dark place,Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(535.17 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

无水乙醇: 45 mg/mL(229.36 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇
动物实验配方：
生物活性
靶点

  • COX-2
描述 Asarylaldehyde (2,4,5-TMBA) is a natural COX-2 inhibitor, which isolated from carrot (Daucus carota L.) seeds significantly inhibits cyclooxygenase II (COX-2) activity at the concentration of 100 μg/mL compared to three commercial nonsteroidal anti-inflammatory drugs Aspinin, Ibuprofen, and Naproxen at their IC50 values 180, 2.52, and 2.06 μg/mL, respectively. 2,4,5-TMBA, a natural inhibitor of cyclooxygenase-2, suppresses adipogenesis and promotes lipolysis in 3T3-L1 adipocytes. When treated with 100 μg/mL of 2,4,5-TMBA for 24, 48, or 72 h, the viability of fully differentiated 3T3-L1 adipocytes is decreased by 8.35, 15.54, and 27.26%, respectively. When the preadiocytes are treated with 100 μg/mL of 2,4,5-TMBA for 24 h before differentiation medium is supplemented, the cell viability is decreased by 26.46%[3]. Asaronaldehyde exhibited significant anti-Candida activity (P = 0.0412). Minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were established as 0.25 and 0.5 mg/mL, respectively. It showed significant inhibition of hyphal form transition in yeast at MIC/2 and MIC/4 values[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.10mL

1.02mL

0.51mL

25.48mL

5.10mL

2.55mL

50.97mL

10.19mL

5.10mL
参考文献

[1]Chen CC, Chyau CC, Hseu TH. Production of a COX-2 inhibitor, 2,4,5-trimethoxybenzaldehyde, with submerged cultured Antrodia camphorata. Lett Appl Microbiol. 2007 Apr;44(4):387-92.

[2]Momin RA, De Witt DL, Nair MG. Inhibition of cyclooxygenase (COX) enzymes by compounds from Daucus carota L. Seeds. Phytother Res. 2003 Sep;17(8):976-9.

[3]Wu MR, Hou MH, Lin YL, Kuo CF. 2,4,5-TMBA, a natural inhibitor of cyclooxygenase-2, suppresses adipogenesis and promotes lipolysis in 3T3-L1 adipocytes. J Agric Food Chem. 2012;60(29):7262-7269

[4]Rajput SB, Shinde RB, Routh MM, Karuppayil SM. Anti-Candida properties of asaronaldehyde of Acorus gramineus rhizome and three structural isomers. Chin Med. 2013;8(1):18. Published 2013 Sep 8