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LG-100064

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Chemical Structure| 153559-46-7 同义名 : -
CAS号 : 153559-46-7
货号 : A123065
分子式 : C23H26O3
纯度 : 99%+
分子量 : 350.45
MDL号 : MFCD13191327
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(142.67 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 LG-100064 is synthetic retinoid (3-methyl-TTNCB) working as a selective pan-RXR agonist with EC50 values of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ, with no activity on RARs. It has affinity to RXRα, RXRβ and RXRγ with Kd values of 350nM, 230nM and 365nM. LG-100064 is capable of inhibiting transglutaminase enzymatic activity with IC50 value of 0.1μM. A 0.1% solution of LG-100064 is capable of inhibiting the utriculi diameter by approximately 50% in Rhino mice topically dosed of LG-100064, with less irritating to the skin of Rhino mice than 9-cis- or all-trans-retinoic acid.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.85mL

0.57mL

0.29mL

14.27mL

2.85mL

1.43mL

28.53mL

5.71mL

2.85mL