产品说明书
Guggulsterone
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同义名 : | Z/E-Guggulsterone;Guggulsterone E&Z;Pregna-4,17(20)-diene-3,16-dione;Guglip |
| CAS号 : | 95975-55-6 | |
| 货号 : | A1229813 | |
| 分子式 : | C21H28O2 | |
| 纯度 : | 98% | |
| 分子量 : | 312.446 | |
| MDL号 : | MFCD01310757 | |
| 存储条件： |
粉末 Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 20 mg/mL(64.01 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Guggulsterone is a phytosterol extracted from the gum resin of the Commiphora wightii tree. Guggulsterone inhibits the growth of many tumour cells. It induces apoptosis by down-regulating anti-apoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP, and survivin), regulating cell cycle proteins (cyclin D1 and c-Myc), activating caspases and JNK, and inhibiting Akt[1].Guggulsterone acts as an FXR antagonist and reduces CDCA-induced FXR activation, with IC50 values of 17 and 15 μM for Z-Guggulsterone and E-Guggulsterone, respectively[2].Guggulsterone inhibited LPS-induced expression of TREM-1, TLR4 and TNF-α as well as phosphorylation of IκBα and NF-κB p65 in RAW 264.7 cells at concentrations ranging from 0.5-20 μM for 24 hours of treatment[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.20mL 0.64mL 0.32mL |
16.00mL 3.20mL 1.60mL |
32.01mL 6.40mL 3.20mL |
| 参考文献 |
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