产品说明书

Olmutinib

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Chemical Structure| 1353550-13-6 同义名 : HM61713, BI 1482694;HM61713;BI 1482694
CAS号 : 1353550-13-6
货号 : A122891
分子式 : C26H26N6O2S
纯度 : 99%+
分子量 : 486.589
MDL号 : MFCD29918158
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(246.61 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • EGFR/ErbB1
描述 Olmutinib (HM61713; BI-1482694) is an orally administered, irreversible inhibitor of the EGFR tyrosine kinase, specifically designed to bind to a cysteine residue close to the kinase domain. It is primarily used in the treatment of non-small cell lung cancer (NSCLC)[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.06mL

0.41mL

0.21mL

10.28mL

2.06mL

1.03mL

20.55mL

4.11mL

2.06mL
参考文献

[1]Kim ES, et al. Olmutinib: First Global Approval. Drugs. 2016 Jul;76(11):1153-7.

[2]Mohamed W. Attwa, et al. Detection and characterization of olmutinib reactive metabolites by LC‐MS/MS: Elucidation of bioactivation pathways. Journal of Separation science. 18 November 2019.