Mefentrifluconazole

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Chemical Structure| 1417782-03-6 同义名 : -
CAS号 : 1417782-03-6
货号 : A1228494
分子式 : C18H15ClF3N3O2
纯度 : 98%
分子量 : 397.779
MDL号 : MFCD31735110
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(263.97 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Mefentrifluconazole, a novel azole derivative, serves as a broad-spectrum antifungal agent in agrochemical applications. It acts as a potent, selective, and orally active inhibitor of fungal CYP51 (Kd=0.5 nM), while exhibiting reduced inhibitory activity against human aromatase (IC50=0.92 μM) [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.51mL

0.50mL

0.25mL

12.57mL

2.51mL

1.26mL

25.14mL

5.03mL

2.51mL
参考文献

[1]Tesh SA, et al. Innovative selection approach for a new antifungal agent mefentrifluconazole (Revysol®) and the impact upon its toxicity profile. Regul Toxicol Pharmacol. 2019 Aug;106:152-168.